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IMPROVED VIABILITY OF OFFSPRING WITH OESTROGEN SUPPLEMENTATION OF OVARIECTOMIZED RABBITS MAINTAINED ON PROGESTERONE

Summary.: Ovariectomized pregnant rabbits given sufficient progesterone maintained their pregnancies well but, after kindling, only a low percentage of young were found alive. Addition of oestradiol to the treatment regimen did not alter the effectiveness of progesterone in preventing abortion but increased the percentage of young found alive after parturition. The beneficial effect of oestrogen appeared to be related to a reduced incidence of prolonged pregnancies and prolonged labours, and suggested a rôle for oestrogen in the successful termination of pregnancy.