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DIFFERENTIAL OVARIAN UPTAKE OF [¹³¹I]ALBUMIN INJECTED INTO ONE UTERINE HORN IN THE GUINEA-PIG

Changes in the permeability of the guinea-pig uterus to [¹³¹I] albumin, injected into the uterine lumen during the oestrous cycle have been investigated to see whether such changes could be linked to the supposed time of release and action of the uterine lytic factor. Since albumin would presumably be cleared mainly by the uterine lymphatics, the existence of utero-ovarian lymphatic connections might account for the local nature of the lytic effect.

Thirteen virgin guinea-pigs (500 to 950 g) from the Institute's own colony were used in these experiments. They were anaesthetized with tribromoethanol ('Avertin', Bayer Products Ltd) supplemented with ether; 'Avertin' abolishes the squirming movements seen when only ether is used. The left carotid artery was cannulated; the cannula (Portex Ltd, i.d. 0·63 mm) was taken through the skin to the back of the