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SERUM LEVELS OF IgG AND -MACROGLOBULIN AND INCIDENCE OF CRYOFIBRINOGENAEMIA IN WOMEN TAKING ORAL CONTRACEPTIVES

The effectiveness and ease of administration of combined oestrogen-progestagen preparations as oral contraceptives generated considerable optimism in the field of fertility control, but the demonstration of associated metabolic changes and side effects has dampened the enthusiasm for a universal acceptance of this technique. The most serious of these complications is thromboembolism. The controversial data reviewed by Doll (1971) indicate that women taking oral contraceptives are at a four to eight times greater risk of developing thrombosis of the deep veins of the lower limbs, pulmonary vessels, cerebrovascular system, mesenteric and other abdominal arteries, hepatic vein radicles and coronary arteries. The delicate physiological balance between the complex systems of blood clotting and fibrinolysis may be disturbed by several means, one of which is the change in -macroglobulin