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UPTAKE OF HORSERADISH PEROXIDASE BY THE TESTIS AND EPIDIDYMIS OF MICE

Mancini, Vilar, Alvarez & Seiguer (1965) have demonstrated the passage through the blood—testis barrier of labelled serum proteins injected intravenously into rats. Horseradish peroxidase was earlier introduced as a tracer by Straus (1957a) and applied to the ultrastructural level by Karnovsky (1965) and Graham & Karnovsky (1966).

Sedar (1966a, b) reported, in two abstracts, that horseradish peroxidase injected intravenously into the hamster became localized in the epididymis and ductuli efferentes, and in the rete testis. Reddy & Svoboda (1967) observed that horseradish peroxidase injected intravenously into the rat was taken up by the cells of the testis. Recently, Fawcett, Leak & Heidger (1970), studying the permeability of the blood—testis barrier in guinea-pigs, reported the uptake of horseradish peroxidase injected interstitially in the testis.

The different results obtained