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TOTAL GLYCEROL IN THE EXCURRENT DUCTS OF THE MALE RAT

Some evidence suggests that the male antifertility agent, 3-chloro-1,2-propanediol, may damage the vascular supply of the rat caput epididymidis and interfere with sperm maturation (Gunn, Gould & Anderson, 1969; Ericsson & Baker, 1970). Gunn et al. (1969) suggested that this chlorhydrin may act through interference with the secretion or utilization of glycerylphosphorylcholine within the epididymis. This proposal was considered because of the already established importance of glycerylphosphorylcholine within this context (Mann, 1964). However, if 3-chloro-1,2-propanediol were metabolized through pathways in which glycerol was the normal substrate, the first point at which to detect this proposed effect of chlorhydrin treatment would be in the total glycerol pool, itself, rather than by measurements of various phospholipid intermediates along the pathway from free