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THE EFFECT OF METABOLIC ALKALOSIS, HYPOTENSION AND INHIBITORS OF CARBONIC ANHYDRASE ON FLUID SECRETION BY RAT TESTES

Summary.: Fluid secretion by rat testes was estimated from the gain in fluid content after efferent duct ligation. Fluid secretion was reduced by metabolic alkalosis induced by intravenous infusions of sodium acetate or bicarbonate but unaffected by the infusion of similar amounts of sodium as sodium chloride. Hypotension had no effect on fluid secretion nor did inhibitors of carbonic anhydrase given by mouth. However, acetazolamide injected intravenously and ethoxzolamide injected intraperitoneally decreased fluid secretion. The results support the theory that fluid secretion is an active process.