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EFFECTS OF HEMICASTRATION AND THE SUBSEQUENT ADMINISTRATION OF DRUGS IN THE MOUSE

Summary.: Compensatory hypertrophy of the remaining testis was not detected in mice hemicastrated at ages varying from 3 to 18 weeks, and killed 1, 2 or 3 weeks later. The response of hemicastrated mice to drugs and sex steroids was tested to see whether these animals were useful in studying the effects of antigonadotrophic substances. Seminal vesicle weight was significantly reduced by oestradiol, progesterone, methallibure and reserpine (though small doses of reserpine caused unexpected increases). Increase in testis weight was significantly reduced by oestradiol, methallibure, chlorpromazine and reserpine. Correction of seminal vesicle and increase in testis weight for initial body weight was found to be valid and useful. Hemicastrated mice were used to test drugs which inhibit the synthesis of biogenic monoamines: p-chlorophenylalanine reduced seminal vesicle weight but -methyltyrosine was without effect.

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