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THE EFFECT ON THE MOUSE ADRENAL X-ZONE OF BLASTOCYSTS TRANSPLANTED UNDER THE KIDNEY CAPSULE

Summary.: A secretion from mouse trophoblast was investigated using the mouse adrenal X-zone, which degenerates differently under the influence of androgens and progestagens. Blastocysts were transplanted under the kidney capsules of female mice and, subsequently, the kidneys and adrenals were examined histologically for trophoblast growth and X-zone degeneration, respectively. Adrenal X-zone degeneration was evident in immature mice only when they received blastocyst transplants, correlating trophoblast proliferation with X-zone degeneration. The degeneration found in both transplanted and control adults correlates maturity with X-zone regression. The fact that the mode of degeneration was always histologically similar to that induced by progestagens implies a progestagenic mediation.