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STIMULATION OF OVULATION IN PSEUDOPREGNANT RATS BY CLOMIPHENE AND RELATED COMPOUNDS

Summary.: Female Wistar rats were made pseudopregnant by electrical stimulation of the uterine cervix and used as models for anovulation. Clomiphene, cyclofenil, epimestrol, and stilboestrol were administered either for 2-day periods at various times of pseudopregnancy, or continuously from Days 3 to 8, or until mating had taken place. All compounds tested stimulated ovulation at certain dose levels, but continuous administration proved to be more effective than the limited treatment. Pregnancies occurred after treatment with all test substances with the exception of clomiphene.