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EFFECT OF MATERNAL AGE ON POSTIMPLANTATION REPRODUCTIVE FAILURE IN MICE

Summary.: Postimplantation reproductive failure was studied in young adult, 9-, 11-, 13- and 15-month-old C57BL/6J mice. Loss of all implanted embryos between the 8th and 18th days of pregnancy increased with advancing maternal age. The percentage of individual postimplantation deaths increased from 9% in young adults to 23% in 9-month-old mice and further increased to 45% in 11-month-old animals. Evidence is presented that deaths most commonly occurred in the early postimplantation period.