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INVESTIGATIONS ON THE MODE OF ACTION OF D-6-METHYL-8-CYANOMETHYLERGOLINE IN SUPPRESSING PREGNANCY IN THE MOUSE

Pregnancy in the rat can be prevented by a single intragastric administration of D-6-methyl-8-cyanomethylergoline (CME), a new synthetic ergoline derivative, during the first 7 days after mating (Reabek, Semonsk & Kucharczyk, 1969). This substance is structurally closely related to the naturally occurring alkaloid, agroclavine, which has been shown to prevent implantation in mice and rats (Mantle, 1969; Edwardson & MacGregor, 1969).

In a preliminary experiment, following the technique (Reabek et al., 1969) successfully used in rats, CME (250 µg in 250 µl of 1 % tartaric acid) was administered to five mice by a single intragastric injection on each of the first 7 days of pregnancy. Eighteen out of thirty-five treated mice remained pregnant in comparison with twenty-three out of thirty-five untreated control mice. Thus, as there was no consistent evidence that implantation

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