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THE TIMING AND VARIATION OF PRE-IMPLANTATION EVENTS IN THE MOUSE

Summary.: Spacing of zygotes, loss of the zona pellucida, and appearance of localized areas of increased vascular permeability at the implantation sites in the uterus were observed in groups of mice examined at 2-hr intervals from 10.00 hours to midnight on Day 4 of pregnancy, and at 02.00, 08.30 and 15.00 hours on Day 5. All the events examined had a 6- to 8-hr variation in their time of occurrence.

Studies of interrelationships between the zygote and the uterus require a precise knowledge of the timing, variation and sequence of the events leading up to implantation in any one species. Previous studies of preimplantation phenomena in the rodent have been based on relatively small numbers of animals examined at irregular intervals during the periods of interest.