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SOME EFFECTS OF OXYTOCIN IN VITRO ON RAT UTERINE SMOOTH MUSCLE

Brief treatment of experimental subjects with progestagens or oestrogens has been shown to achieve a marked modification of the response to oxytocin (Burnstock, Holman & Prosser, 1963; Reynolds, 1965). Isolated uterine muscle, when stretched, liberates a substance that slowly increases uterine tone to the point of contracture (Jung, 1966) but with an isometric method the problems of unrecorded stretch do not arise (Schofield, 1954; Csapo, 1954). With these points in mind, two experiments were undertaken to define the effects of oestrogen and progestagens on the response of the myometrium to stimulus with synthetic oxytocin. Both experiments were based on a block-type factorial model (Snedecor, 1956) in which the treatment of each of the three experimental groups was repeated four times.

Thirty-six Sprague-Dawley female rats in the prepubertal stage were bilaterally ovariectomized under ether