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THE EFFECTS OF MATERNAL PRE-IMMUNIZATION ON PREGNANCY IN THE MOUSE

Summary.: Before mating with males of the A₂G or CBA inbred strains of mice, C57BL females were immunized against either the paternal strain antigens (allogeneic) or Peromyscus species antigens (xenogeneic). Evidence is presented which indicates that, contrary to earlier reports, pre-immunization has no effect on placental size, but may reduce foetal weight and litter size. The rôles of specific immunity and non-specific `stress' are discussed.