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EFFECTS OF CHLORHYDRIN UPON THE FERTILITY OF SPERMATOZOA OF THE CAUDA EPIDIDYMIDIS OF THE RAT

Male rats receiving daily injections of -chlorhydrin (U-5897) at a dose of 7 to 8 mg/kg become infertile (Ericsson, 1969; Ericsson & Baker, 1970). Fertility is lost within 4 to 5 days of the beginning of treatment and returns within 1 week of withdrawal of the drug. It has been proposed that -chlorhydrin acts preferentially on the epididymis rather than the testis, and that it particularly affects the head of the epididymis, possibly through interference with its normal blood supply (Ericsson, 1969). This, in turn, might hinder maturation of the contained spermatozoa. On the other hand, large doses of the drug are known to give rise to impaired motility in mature spermatozoa (Coppola, 1969; Samojlik & Chang, 1970) and changes in epididymal blood flow incurred by use of the drug have been shown