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SYNERGISM BETWEEN LH AND FSH IN THE INDUCTION OF OVULATION

Summary.: A possible synergistic participation of LH and FSH in the ovulatory process was explored by intravenous administration of subthreshold doses of LH and/or FSH to rats with 4-day oestrous cycles, in which ovulation was blocked by a potent anti-oestrogen—ICI 46,474. The individual gonadotrophins in the doses used were only marginally active in restoring ovulation but, when given in combination, they potentiated the incidence of ovulation in four different experiments. It is postulated that both LH and FSH synergize with each other in the induction of ovulation as they do in causing growth of follicle.