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PATTERNS OF DISTRIBUTION AND URINARY EXCRETION OF MALE RAT ACCESSORY SEX GLAND-SPECIFIC ANTIGENS

Summary.: Patterns of distribution of organ-specific antigens in the accessory sex glands of the male rat and the urinary excretion of these antigens were investigated by the immunodiffusion and immunofluorescence microscopical techniques. One organ-specific antigen was detected in the bulbo-urethral gland, two antigens were found in the prostatic gland and three common ones in the ampullary gland, seminal vesicle and coagulating gland. The antigens were localized immunohistologically in the epithelial cytoplasm and luminal excretory products of the glands. The antigens of the accessory glands were demonstrated in the urine, the only exception being the antigen of the bulbo-urethral gland. There were irregular variations in the urinary excretion of the antigens of the individual glands. The prostatic constituents were found to be the main contributors of the accessory glands to the urinary protein pool.