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STIMULATION OF RNA SYNTHESIS IN THE BLASTOCYST AND UTERUS OF THE RAT BY ADENOSINE 3'5'-MONOPHOSPHATE (CYCLIC ApMP)

In earlier studies which showed that oestrogen activates the synthesis of RNA, DNA and protein in the blastocyst and uterus during delayed implantation, it was postulated that activation of the delayed blastocyst might be due to the direct action of oestrogen (Mohla, 1968; Prasad, Dass & Mohla, 1968; Dass, Mohla & Prasad, 1969).

One of the earliest effects of oestrogen on the rat uterus is the release of adenosine 3'5'-monophosphate (cyclic ApMP), the levels of which are enhanced within 15 sec after the intravenous administration of oestrogen (Szego & Davis, 1967). Griffin & Szego (1968) showed that cyclic ApMP, like oestrogen, enhanced within 5 min the incorporation of labelled amino acids into the protein of uterine segments of untreated ovariectomized rats. They postulated that the cyclic ApMP released as a result of oestrogen treatment also participates in the early effects of oestrogen on the uterus. A further effect,