This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by DEBELJUK, L. Search for Related Content PubMed PubMed Citation Articles by DEBELJUK, L.

LACK OF GONADOTROPHIN-INHIBITING ACTIVITY OF OVINE PINEAL EXTRACTS

Several investigators have reported that defatted pineal extracts exert inhibitory effects on the secretion and activity of adenohypophysial gonadotrophins. Moszkowska (1965) found that such extracts inhibited the release of gonadotrophins by the adenohypophysis in vitro and Soffer, Vogel & Rudavsky (1965) reported that these extracts abolished the stimulatory effect of hcg and HMG on the uterine weight of the female rat. It has also been reported (Thieblot, Alassimone & Blaise, 1966) that defatted pineal extracts produce a decrease in the pituitary gonadotrophin activity of castrated male rats. Other authors, however, have observed contradictory effects with crude extracts, which have been interpreted as indicating the presence of stimulatory and inhibitory factors (Reiss, Davis, Sideman, Mauer & Plichta, 1963). On the other hand, Prop & Ebels (1968) did not observe any effect