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It has been postulated that the uterus in the sheep is either directly or indirectly responsible for the regulation of the life-span of the corpus luteum (CL) (see recent reviews by Ginther, 1967; Melampy & Anderson, 1968; Caldwell, Rowson, Moor & Hay, 1969). A local relationship between each uterine horn and the adjacent ovary has been suggested, since the lack of one of the uterine horns, achieved by partial (unilateral) hysterectomy, appears to prolong the life-span of CL in the ipsilateral ovary, but has no such effect on CL in the ovary adjacent to the remaining horn (Inskeep & Butcher, 1966; Moor & Rowson, 1966). An alternative explanation, suggested by Moor & Rowson (1966) and emphasized by Nalbandov & Cook (1968), is that it is the effect of the surgery itself rather
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