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ANTI-ANDROGENIC ACTIVITY OF 7,8,9,10-TETRAHYDRO-7-OXO-BENZO (C) PHENANTHRIDINE (A¹¹-IV) ON IMMATURE, CASTRATED, MALE RATS

Summary.: One of the aza-analogues, 7,8,9,10-tetrahydro-7-oxo-benzo (c) phenanthridine exhibited an anti-androgenic activity on immature, castrated, male rats. The compound had an interesting anti-androgenic activity as the effect of testosterone-induced gain in weight of the ventral prostate was significantly inhibited by the compound. This compound did not, however, inhibit the androgen-induced weight increase of the seminal vesicle.