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QUANTITATIVE CHANGES IN UTERINE NUCLEIC ACIDS DURING THE OESTROUS CYCLE IN RATS

Summary.: Changes in levels of RNA and DNA in rat uterus have been measured throughout the oestrous cycle in two strains of rats by a method designed specifically for application to uterine tissue. It has been shown that there are significant cyclic variations of RNA and DNA, dry matter and water content, but none in total nitrogen in the uteri of Sprague-Dawley rats with a 5-day cycle, and no significant changes, except in RNA, in the uteri of a Wistar strain with a 4-day cycle. In the Sprague-Dawley rats, RNA/DNA ratios were highest in pro-oestrus and oestrus, and lowest in di-oestrus, the increase in RNA/cell preceding the period of maximum growth and total nitrogen content in the uterus during the cycle.