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EARLY ACTIONS OF CADMIUM IN THE RAT AND DOMESTIC FOWL TESTIS

Summary.: Male rats and domestic fowl were injected with ¹⁰⁹Cd. After anaesthesia, blood was taken from the exposed heart and also various tissues were taken. The level of ¹⁰⁹Cd was determined in each tissue.

In rats injected subcutaneously, there was a steady increase in the level of ¹⁰⁹Cd for 40 min, followed by a drop in the whole testis, seminal vesicles, epididymis, skeletal muscle, heart, spleen, pancreas and liver. In the blood, the maximum level of ¹⁰⁹Cd was reached at 10 min and dropped rapidly. In the ileum, duodenum, and kidney there was an increase for 80 min.

In most tissues of the intraperitoneally-injected rats, ¹⁰⁹Cd reached the highest level at 2·5 min and tended to decrease thereafter. The amount of ¹⁰⁹Cd in the blood reached a peak at 5 min and then dropped. Liver levels rose continually, while in the kidney, ileum and duodenum, levels rose for 40 min, then tended to drop.

In most tissues of the fowl, including the blood, the level of ¹⁰⁹Cd rose gradually and dropped gradually. Levels in the kidney and liver showed a continual increase.