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IMMUNOLOGICAL ASPERMATOGENESIS IN MAN

Summary.: Lymphocytes from twenty-one (16·6%) of 126 men with non-obstructive azoospermia or severe oligospermia showed blastoid transformation in culture when exposed to normal semen homogenate, indicating their ability to produce antibodies against seminal antigen (s).

In the diagnosis of aspermatogenesis of immunological origin, the blastoid transformation test is believed to have advantages over other tests which depend on the direct estimation of circulating antibodies against spermatozoa.

There is evidence that testicular injury may be involved in the production of immunological aspermatogenesis in man.