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Summary.: A study of the correlation between a positive spot test for chloride in cervical mucus and the occurrence of ovulation, as indicated by the peak of the karyopycnotic index in the vaginal smear, has been made. The brightest positive spot coincides with, or occurs a few days before, the probable day of ovulation—too late to be of value for contraception by the rhythm method but of potential value to couples desiring conception, especially as the woman can easily use the test herself. Anovulatory patients treated with gonadotrophins show a positive chloride spot when the ovary responds to follicle-stimulating hormone.
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