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THE CELLULAR RESPONSE OF THE UTERUS OF THE AGED MOUSE TO OESTROGEN AND PROGESTERONE

The uterus of the aged mouse does not respond to a decidual stimulus as efficiently as that of a young mouse (Finn, 1966a; Talbert & Krohn, 1966) and it is suggested that this may contribute to the decline of litter size in old mice. In young mice, closure of the uterine lumen (Potts, 1966; Finn & McLaren, 1967) and stromal cell proliferation (Finn & Martin, 1967) occur just before implantation, and are probably important in the preparation of the uterus for implantation and decidual cell formation. Both changes can be induced in ovariectomized mice; stromal proliferation by the administration of a small dose of oestrogen following several days' treatment with progesterone (Martin & Finn, 1968) ; luminal closure by progesterone alone (Martin, Finn &