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DEPRESSION OF DECIDUAL GROWTH IN THE RAT WITH LH ANTISERUM AND PITUITARY AUTOTRANSPLANTATION

Summary.: Rabbit antiserum to sheep LH inhibited uterine growth in adult rats following uterine trauma on Day 4 of pseudopregnancy. The weights of the horns subjected to trauma were similar to those obtained in rats ovariectomized at the time of trauma and given only progesterone, and in rats with the adenohypophysis transplanted beneath the kidney capsule on the day of ovulation. Antiserum to LH given to rats with an autotransplanted pituitary did not alter decidual growth. Oestrone restored maximal uterine growth in rats receiving LH antiserum and in rats with an autotransplanted pituitary. Simultaneous injections of FSH and LH resulted in maximal decidual cell response in pituitary autotransplanted rats, while either, given alone, had only slight stimulatory effects. It is suggested that LH antiserum inhibits the oestrogen production necessary for maximal uterine growth. Luteinizing hormone does not appear to be necessary, unless in minute quantity, for production of progesterone in amounts large enough to support maximal uterine growth after trauma.