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EFFECT OF A SINGLE DOSE OF HUMAN CHORIONIC GONADOTROPHIN ON THE OVULATORY RESPONSE OF THE IMMATURE RAT

It has been reported that a single dose of human chorionic gonadotrophin (HCG) is capable of inducing ovulation within 24 hr in a variety of adult rodents and in the rabbit when administered in late di-oestrus or oestrus (Saunders, 1947; Mitchell & Yochim, 1968), in pregnancy (Burdick & Ciampa, 1944; Rowlands, 1956; Greenwald, 1964, 1966, 1967; Adams, 1968) and during lactation (Greenwald, 1965). The purpose of the present experiments was to determine whether a single injection of HCG would induce ovulation in the immature rat.

The Wistar strain of rats, aged 19 to 31 days at the beginning of treatment, was used and the animals were kept in an air-conditioned room, the temperature was 25 ± 1·0° C with 12 hr light and 12 hr of darkness.

The first experiment was carried out on the time relationship between the administration of HCG and the occurrence of ovulation. The 25-day-old rats