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INHIBITION OF HCG-INDUCED OVULATION BY ANTI-HCG SERUM IN IMMATURE MICE PRE-TREATED WITH PMSG

Summary.: Intravenous and subcutaneous injections of HCG were compared for their effectiveness in inducing ovulation in mice pre-treated with PMSG.

Anti-HCG and anti-PMSG sera, prepared in rabbits, were used to determine the time required for HCG and PMSG to induce ovulation following pre-treatment with PMSG. The antisera were injected at various times after the injection of HCG and PMSG, as ovulating hormones, and it was found that ovulation was completely blocked when the hormone and its antiserum were administered simultaneously by intravenous injection. When the injection of antiserum was delayed for 2 hr, all mice ovulated normally.

From these results, it was concluded that irreversible changes in ovulation occurred in the mature follicles within 2 hr of the administration of the ovulatory gonadotrophin and that no circulating gonadotrophin was needed after that time for completion of ovulation.