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INCORPORATION OF LABELLED NUCLEOSIDES IN VITRO BY RABBIT AND MINK BLASTOCYSTS IN THE PRESENCE OF BLASTOKININ OR SERUM

Summary.: The effects of the rabbit uterine fluid component, blastokinin (BKN), and rabbit serum on nucleic acid synthesis in rabbit and mink blastocysts were examined. [³H] Thymidine incorporation was not enhanced by BKN in rabbit embryos explanted on the 3rd to 5th days post coitum, but thymidine uptake was somewhat greater in 4- and 5-day blastocysts in serum-containing medium than in the controls in defined medium. [³H] Uridine incorporation was inhibited slightly by serum and significantly stimulated by BKN in 5-day rabbit blastocysts, but not in younger ones. Rabbit serum inhibited uridine uptake in mink blastocysts, while BKN had no effect.