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EFFECTS OF A HEXOESTROL DERIVATIVE, ERYTHRO-MEA, ON EARLY PREGNANCY IN THE MOUSE

Summary.: The effects of erythro-MEA (erythro-ethyl-'-methyl-4,4'dihydroxybibenzyl) on tubal transport and implantation in the mouse were studied. When given on Days 1 to 3 of pregnancy, erythro-MEA causes tube-locking of some ova, reduces the recovery of ova to 60% of that in controls, and has similar effects to oestradiol. Treatment with this compound inhibits the deciduoma reaction and implantation of transferred ova in pseudopregnant and progesterone-treated, ovariectomized mice. When given to mice with delayed blastocysts, erythro-MEA induces implantation in 50% of mice and prevents oestradiol-induced implantation in others. In this system, erythro-MEA has both oestrogenic and antioestrogenic properties, but it is concluded that its anti-fertility actions may, in part, be due to its anti-oestrogenic property.