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EFFECT OF HYPOTHALAMIC DE-AFFERENTATION ON INDUCTION OF PSEUDOPREGNANCY BY VAGINAL-CERVICAL STIMULATION IN THE RAT

It is well known that mechanical or electrical stimulation of the uterine cervix activates the corpora lutea of the rat and induces pseudopregnancy as effectively as does mating with a vasectomized male (Everett, 1964). Evidence from recent studies on the effects of electrical stimulation of the hypothalamus (Everett & Quinn, 1966) and of hypothalamic lesions (Flerkó, 1960; McCann & Friedman, 1960) suggests that an important neurogenic component for the activation of the corpora lutea exists in the hypothalamus. Little is yet known, however, of the pathways whereby information is conveyed from the genitalia to the hypothalamus controlling the secretion of pituitary luteotrophic hormone (LH). In the present study, the surgical transection of neural connections to the hypothalamus (Halász & Pupp, 1965; Halász & Gorski, 1967) was employed to investigate the pathways by which