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ALKALINE PHOSPHATASE IN PRE-DECIDUAL CELLS OF THE HUMAN ENDOMETRIUM

During the menstrual cycle, the human endometrium shows alterations in the activity of alkaline phosphatase in respect of both localization and amount. The changes in enzyme activity in the epithelial cells of the glands, and in the endothelium of blood vessels, have been consistently demonstrated histochemically (Atkinson & Engle, 1947; McKay, Hertig, Bardawil & Velardo, 1956) and are well known. Enzyme activity in the stromal cells of the endometrium is denied by all published work except that of Mookerjea (1961), who described a peak of alkaline phosphatase activity in these cells at the end of the follicular phase of the cycle. Because most studies of alkaline phosphatase in the endometrium have used tissue fixation, which is known to destroy much of the enzyme, it was decided to examine fresh