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THE EFFECT OF CADMIUM CHLORIDE ON THE BLOOD-TESTIS BARRIER OF THE GUINEA-PIG

Cadmium exerts a selective toxic effect on the blood vessels of the testis and caput epididymidis (Gunn, Gould & Anderson, 1963; Chiquoine, 1964; Mason & Young, 1967) and investigations into the changes in blood flow and vascular permeability suggest that the primary site of action is the end-arterial bed (Niemi & Kormano, 1965; Waites & Setchell, 1966; Clegg & Carr, 1966; Gupta, Barnes & Skelton, 1967). The resulting ischaemia and interstitial oedema then cause failure of spermatogenesis (Mason & Young, 1967).

Dye studies suggest that a barrier exists at the tubular as well as the vascular level (Kormano, 1967a, b), and the presence of this barrier is essential for the production of a testicular fluid differing in composition from serum (Setchell, 1967; Setchell, Dawson & White, 1968; Johnson & Setchell, 1968). The present study shows that, in the untreated guinea-pig

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