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CONTINUOUS ORAL ADMINISTRATION OF MEGESTROLACETATE TO WOMEN

Summary.: Twenty women were treated orally during sixty menstrual cycles with 500 µg megestrolacetate daily. Ovulation was not inhibited. In 13% of the cycles (four of the twenty patients treated) breakthrough bleeding occurred, suggesting that megestrolacetate in the doses employed exerts an influence on the endometrium. Administration of 500 µg daily does not have a thermogenic effect. BBT showed a normal biphasic pattern. Ferning and spinnbarkeit of cervical mucus were absent and the mucus became opaque. Post-coital tests became poor or negative. Data are presented suggesting an influence of megestrolacetate on cervical mucus and on the vaginal epithelium.