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THE DURATION OF AN FSH EFFECT IN VITRO

Summary.: Mouse ovaries were incubated with FSH then removed to fresh medium lacking hormone. At various times after removal, [¹⁴C]thymidine was added to the dishes. After 24-hr further incubation, the tissue was prepared for counting. Parallel cultures, never exposed to FSH, received thymidine and were counted simultaneously. The difference in counts between paired FSH-treated and untreated cultures indicated the residual FSH effect. The differences were significant up to 9 hr after removal from FSH, but not thereafter. The results suggest that a constant supply of FSH is needed for the continued growth of early follicles.