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OVIDUCT CIRCULAR MUSCLE RESPONSE TO DRUGS RELATED TO THE AUTONOMIC NERVOUS SYSTEM

Summary.: The influence of various autonomic drugs on the circular muscle of the oviduct was studied. The changes in oviduct motility patterns were measured in anaesthetized Dutch Belted rabbits with a perfusion apparatus and pressure transducer. Intravenous noradrenaline (1 to 4 µg/kg) and adrenaline (2·5 to 7·5 µg/kg) resulted in a sustained contraction of the oviduct followed by contraction at a higher tone. Isoprenaline (1 to 4 µg/kg) caused a relaxation of the oviduct musculature. Phenoxybenzamine (3 mg/kg subcutaneously) blocked the action of adrenaline for at least 4 hr. Propranolol blocked the action of isoprenaline for 1 to 2 hr. The results of administering acetylcholine and scopolamine were inconclusive.