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CAN BEADS STIMULATE A DECIDUAL RESPONSE IN THE MOUSE UTERUS?

The first indication of a local decidual response to the presence of blastocysts in the mouse uterus is the appearance of Pontamine Blue reactivity at the end of the 4th day of pregnancy (Orsini & McLaren, 1967; Finn & McLaren, 1967). The factor inducing this response is unknown. The time relations make it unlikely that the appearance of W-bodies in the uterine endometrium is involved. Blandau (1949) claimed that in rats, though not in guinea-pigs, glass beads inserted into a pseudopregnant uterus during the sensitive period were sufficient to stimulate a decidual response, suggesting that, in pregnancy, the physical pressure of the blastocyst in the uterine lumen acts as the inducing factor. The present study was designed to show whether beads would stimulate a decidual response in mice.

Females of the randomly bred Q strain were mated to vasectomized Q