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INVESTIGATION OF BLOCK TO GONADOTROPHIN RELEASE IN MATURE FEMALE RATS

Summary.: The block to gonadotrophin release in mature female rats caused by an oestrogen, a progestin and an androgen has been investigated by replacement with pregnant mare serum gonadotrophin (PMSG) and human chorionic gonadotrophin (HCG). Inhibition of ovulation produced by the progestin could be reversed by HCG alone but the effects upon ovulation of oestrogen and androgen were not reversed unless both PMSG and HCG were supplied. The relevance of the results to previous work in the rat and other species is discussed.