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CONCEPTION CONTROL BY MONTHLY INJECTIONS OF MEDROXYPROGESTERONE SUSPENSION AND A LONG-ACTING OESTROGEN

Summary.: An injectable mixture of 25 mg of medroxyprogesterone with 5 mg of oestradiol cypionate was administered monthly to a group of women of reproductive age for a period of 4 to 15 months. The treatment produced sterility in all patients. Minor changes in menstrual pattern were reported, but cyclic bleeding similar to menstruation was preserved in 85·1% of all cycles. Aside from the changes in menstrual pattern, no important side effects resulted from the treatment. Endometrial biopsies performed during the first months revealed distinct phases of endometrial proliferation and secretion, but after 6 months endometrial hypoplasia became the dominant feature. One indication that patients found the treatment acceptable was the low 'drop-out' rate (less than 5% at the end of 9 months). The treatment is proposed as an effective method of conception control.