This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by GUNN, S. A. Articles by ANDERSON, W. A. D. Search for Related Content PubMed PubMed Citation Articles by GUNN, S. A. Articles by ANDERSON, W. A. D.

MECHANISMS OF ZINC, CYSTEINE AND SELENIUM PROTECTION AGAINST CADMIUM-INDUCED VASCULAR INJURY TO MOUSE TESTIS

Summary.: It is known that the selective injurious effect of cadmium on the testis can be prevented by zinc, cysteine or selenium. Studies, conducted in CD-1 mice, were initiated to determine whether any of these treatments offered protection by preventing cadmium from reaching the testis in doses sufficient to cause injury. Using cadmium chloride, labelled with ¹⁰⁹Cd, it was shown that none of these protective agents decreased the amount of cadmium reaching the testis. Zinc acetate evoked no significant changes, cysteine brought about a slight enhancement of cadmium level but selenium dioxide produced a marked and prolonged elevation of cadmium uptake by the testis. Comparable studies in which selenium, rather than cadmium, was labelled (⁷⁵Se) demonstrated that, in the presence of cadmium, selenium levels were augmented. Possible mechanisms are discussed to explain the diverse means of protection offered by zinc, cysteine and selenium. Since the site of cadmium-induced testicular injury has been pin-pointed at its vasculature, it is suggested that these protective agents exert their action at the vascular level.

This article has been cited by other articles:

				S. H. Benoff, C. Millan, I. R. Hurley, B. Napolitano, and J. L. Marmar Bilateral increased apoptosis and bilateral accumulation of cadmium in infertile men with left varicocele Hum. Reprod., March 1, 2004; 19(3): 616 - 627. [Abstract] [Full Text] [PDF]

				N. G. Carmichael, B. L. Backhouse, C. Winder, and P. D. Lewis Teratogenicity, Toxicity and Perinatal Effects of Cadmium Human and Experimental Toxicology, March 1, 1982; 1(2): 159 - 186. [PDF]