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Summary.: Bovine placental aldose reductase has been partially purified from foetal cotyledons and the levels of activity measured in forty samples from foetuses 1 to 9 months old. A statistically significant increase in the specific activity of the enzyme with advancing pregnancy was observed.
No significant correlation was found between aldose reductase activity and foetal blood fructose levels.
The increase in enzyme activity during pregnancy followed a pattern similar to that previously observed for urinary oestrogens in cows.
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