This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by GREGOIRE, A. T. Articles by ADAMS, A. Search for Related Content PubMed PubMed Citation Articles by GREGOIRE, A. T. Articles by ADAMS, A.

THE APPEARANCE OF UNIFORMLY LABELLED ¹⁴C-GLUCOSE IN RAT VAGINAL FLUID AND GENITAL TRACT TISSUE

Various attempts have been made to utilize the absorptive properties of the vagina for administration of therapeutic drugs. The vaginal absorption of organic elements, their subsequent isolation in urine, serum or manifestation of their endocrine effects, has been demonstrated with phenylmercuric acetate in the human (Eastman & Scott, 1944) and rat (Laug & Kunze, 1949), and with insulin in the dog (Fischer, 1923) but not the human (Woodyatt, 1922). Penicillin is absorbed within 60 min by the human vagina (Lovelady, Randall & Hosfeld, 1946; Goldberger, Walter & Lapid, 1947), while vaginal absorption of sulphanilamides exhibits daily variation (Carrington, Rohrer, Jones & Moore, 1944).

While investigating oestrogen metabolism, the uptake of tritiated oestrogens by spayed mouse genital tissues after intravenous (Stone, Baggett & Donnelly, 1963), subcutaneous (Stone, 1963) or