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BIOSYNTHESIS OF STEROIDS BY GRANULOSA CELLS OF THE PORCINE OVARY IN VITRO

Summary.: Incubation of granulosa cell aggregates from porcine ovarian follicles with progesterone-4-^{1 4}C, 17-hydroxyprogesterone-4-¹⁴C, pregnenolone-7-³H, testosterone-4-^{1 4}C and androstene-3,17dione-4-¹⁴C showed that they contained efficient 3β-hydroxysteroid dehydrogenase, 20-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase enzyme activities. There were also some aromatizing and probably some 21-hydroxylating enzyme activities. The granulosa cells were particularly low in 17-hydroxylase and sidechain cleaving enzyme activities although some activity was demonstrated.