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EFFECT OF Sc. 11800 (ETHYNODIOL DIACETATE) ON THE GENITAL TRACT OF WOMEN

Summary.: Ethynodiol diacetate (Sc. 11800) was given in various dosages from the 5th day of a cycle for 20 days (2, 1 and 0·5 mg, in combination with 0·1 mg mestranol) to a group of normally menstruating women.

The histological changes in the endometrium on different days of therapy are compared at the different dose levels. Changes in vaginal cytology and cervical mucus during the therapy cycle with different dosages of this drug are discussed.

It is suggested that the low dosage progestin—oestrogen combination may prove a better and a cheaper oral contraceptive.