Reproduction  
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS  
Reproduction (2008) 136 131-146
DOI: 10.1530/REP-07-0576
Copyright © 2008 Society for Reproduction and Fertility
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
136/2/131    most recent
REP-07-0576v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zamudio, N. M
Right arrow Articles by O'Bryan, M. K
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zamudio, N. M
Right arrow Articles by O'Bryan, M. K

REVIEW

Epigenetic regulation in male germ cells

Natasha M Zamudio1,2, Suyinn Chong3 and Moira K O'Bryan1,2

1 Monash Institute of Medical Research, Monash University, Melbourne, Victoria 3168, Australia2 Australian Research Centre of Excellence in Biotechnology and Development, Monash University, Melbourne, Victoria 3168, Australia3 Queensland Institute of Medical Research, Brisbane, Queensland 4072, Australia

Correspondence should be addressed to M K O'Bryan; Email: moira.obryan{at}med.monash.edu.au

In recent years, it has become increasingly clear that epigenetic regulation of gene expression is critical during spermatogenesis. In this review, the epigenetic regulation and the consequences of its aberrant regulation during mitosis, meiosis and spermiogenesis are described. The current knowledge on epigenetic modifications that occur during male meiosis is discussed, with special attention on events that define meiotic sex chromosome inactivation. Finally, the recent studies focused on transgenerational and paternal effects in mice and humans are discussed. In many cases, these epigenetic effects resulted in impaired fertility and potentially long-ranging affects underlining the importance of research in this area.




This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
C. L. Borg, K. M. Wolski, G. M. Gibbs, and M. K. O'Bryan
Phenotyping male infertility in the mouse: how to get the most out of a 'non-performer'
Hum. Reprod. Update, March 1, 2010; 16(2): 205 - 224.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
L. Visser and S. Repping
Unravelling the genetics of spermatogenic failure
Reproduction, February 1, 2010; 139(2): 303 - 307.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
M. L. Martinez-Frias
Can our understanding of epigenetics assist with primary prevention of congenital defects?
J. Med. Genet., February 1, 2010; 47(2): 73 - 80.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
M. A. Santos, E. W Kuijk, and N. S Macklon
The impact of ovarian stimulation for IVF on the developing embryo
Reproduction, January 1, 2010; 139(1): 23 - 34.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS  
Copyright © 2008 by the Society for Reproduction and Fertility.