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The role of glia in the hypothalamus: implications for gonadal steroid feedback and reproductive neuroendocrine output

Instituto Cajal, CSIC, Avenida Doctor Arce 37, E-28002 Madrid, Spain¹ Neuroscience Program² Department of Cell Biology, Neurobiology and Anatomy, Loyola University Chicago, Maywood, Illinois 60153, USA

Correspondence should be addressed to L M Garcia-Segura; Email: lmgs{at}cajal.csic.es

Neuron-to-glia, glia-to-neuron, and glia-to-glia communication are implicated in the modulation of neuronal activity and synaptic transmission relevant to reproduction. Glial cells play an important role in neuroendocrine regulation and participate in the sexual differentiation of neuronal connectivity of brain regions involved in the control of reproductive neuroendocrine output. During puberty, modifications in the morphology and chemistry of astrocytes and tanycytes in the hypothalamus and median eminence influence the maturation of the neuronal circuits controlling the secretion of GnRH. During adult reproductive life, the glial cells participate in the transient remodeling of neuronal connectivity in the preoptic area, the arcuate nucleus, the median eminence, and other brain regions involved in the control of reproduction. Gonadal hormones regulate glial plasticity by direct and indirect effects and regulate various other endocrine signals, local soluble factors and adhesion molecules that also affect glial function and glia-to-neuron communication. The glial cells, therefore, are central to the coordination of endocrine and local inputs that bring about neural plasticity and adapt reproductive capacity to homeostatic signals.

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