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Sex-specific expression of a novel gene Tmem184a during mouse testis differentiation

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia, ¹ Human Molecular Genetics Laboratory, Prince Henry’s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria 3168, Australia ² Murdoch Children’s Research Institute and Department of Paediatrics, University of Melbourne, Royal Children’s Hospital, Parkville, Victoria 3052, Australia

Correspondence should be addressed to P Koopman; Email: p.koopman{at}imb.uq.edu.au

During mouse embryogenesis, the fate of the bipotential gonads is sealed around 10.5 days post coitum (dpc) when the Y-linked gene Sry specifies the differentiation of testes in males, whereas in females, absence of Sry results in ovary formation. Apart from the pivotal action of Sry, many other genes are known to be involved in sex determination and subsequent differentiation. Much is still unknown regarding the regulatory hierarchy governing these events and many more sex differentiation genes are yet to be discovered. In this study, we investigated the expression of Tmem184a, a novel gene encoding a protein of unknown function, but with predicted kinase activity, during mouse embryogenesis. We show that Tmem184a is expressed at high levels in the developing testis from 11.5 dpc, a time of active proliferation and differentiation. Tmem184a expression is further shown to be expressed exclusively within the Sertoli cells of the developing testis cords, suggesting that it may mediate sex-specific signaling events during Sertoli cell differentiation.

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