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A revised model for spermatogonial expansion in man: lessons from non-human primates

Department of Cell Biology and Physiology, Center for Research in Reproductive Physiology, University of Pittsburgh School of Medicine, W952 Biomedical Sciences Tower, 3500 Terrace Street, Pittsburgh, Pennsylvania 15261, USA

Correspondence should be addressed to S Schlatt; Email: schlatt{at}pitt.edu

We have recently described a revised scheme for spermatogonial expansion in non-human primates. We proposed that A_pale-spermatogonia act as self-renewing progenitors and premeiotic germ cells are organized and divide as small clones. Here, we are revisiting the model described for man and propose a modified scheme for spermatogonial expansion. Our revised model shows high similarity to the scheme proposed for non-human primates and is in accordance with all previous and present data.

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