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Gene and protein expression in the myometrium in pregnancy and labor

¹ Institut National de la Santé et de la Recherche Médicale, Unité 767, Paris, F-75014, France and ² Institut National de la Recherche Agronomique, Biologie du Développement et Reproduction, Centre de Recherches de Jouy, Jouy-en-Josas, F-78352, France

Correspondence should be addressed to G Germain; Email guy.germain{at}jouy.inra.fr

Microarray technologies widen our comprehension of the major structural and metabolic transformations which affect the myometrium from the very beginning of pregnancy until parturition. The results are coherent with the mass of information which was accumulated previously, primarily on the basis of studies of selected critical factors. They highlight the activation of precise signaling pathways, some of which may have been previously under evaluated. The remodelling and maturation processes that the myometrium undergoes in pregnancy appear clearly as phenomena which last during the full course of gestation. Comparatively, the onset of labor is perhaps the phenomenon which remains the least well described by these methods of analysis. Nevertheless, genomic studies constitute a necessary first step of orientation and help establishing new links between the generic signaling pathways that are activated during the normal or pathological gestation. These studies also represent an indicative step that will have to be paralleled, in the future, with the results of the systematic proteomic analysis of the myometrium.

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